An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling
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چکیده
منابع مشابه
An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling
Signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedgehog. Here, we find that when activated G protein-coupled receptors (GPCRs) fail to undergo BBSome-mediated retrieval from cilia back into the cell, these GPCRs concentrate into membranous buds at the tips of cilia before release into extracellular vesicles named ectosomes. Unexpectedly, actin and the a...
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ژورنال
عنوان ژورنال: Cell
سال: 2017
ISSN: 0092-8674
DOI: 10.1016/j.cell.2016.11.036